Antibiotika-Therapie

Studien zum Thema:

  • Bayer ME, Zhang L, Bayer MH. Borrelia burgdorferi DNA in the urine of treated patients with chronic Lyme disease symptoms. A PCR study of 97 cases. Infection 1996; 24 No.5.
  • Cameron, DJ. Lyme Disease Clinical Trial – Effectiveness of Retreatment on Health-Related Quality of Life. Abstract, Lyme & Other TBDs: Emerging Tick Borne Diseases, Fri Oct 28th, 2005, Philadelphia, PA.
  • Cimmino MA, Accardo S. Long term treatment of chronic Lyme arthritis with Benzathine penicillin. Ann Rheum Dis 1992 Aug; 51(8):1007-8.
  • Cimmino MA, Moggiana GI, Parisi M, Accardo S. Treatment of Lyme arthritis. Infection 1996 Jan-Feb; 24(1):91-3.
  • Cimperman J, Maraspin V, Lotric-Furlan S, Ruzic-Sabljic E, Strle F. Lyme meningitis: a one-year follow up controlled study. Wien Klin Wochenschr 1999; 111(22-23):961-3.
  • Cimmino MA, Moggiana GI, Parisi M, Accardo S. Treatment of Lyme arthritis. Infection 1996 Jan-Feb; 24(1):91-3.
  • Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, Golightly MG. Seronegative Lyme disease. Dissociation of specific T- and B-lymphocyte responses to Borrelia burgdorferi. N Engl J Med 1988 Dec 1; 319(22):1441-6.
  • Donta ST. Tetracycline therapy for chronic Lyme disease. Clin Infect Dis 1997; 25 Suppl 1:pS52-6.
  • Fallon BA et al. Repeated antibiotic treatment in chronic Lyme disease. J Spirochet Tick Borne Dis, 1999 Fall/Winter:p94-101.
  • Fallon BA et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology, 2007.
  • Gasser R, Reisinger E, Eber B, Pokan R, Seinost G, Bergloff J, Horwarth R, Sedaj B, Klein W. Cases of Lyme borreliosis resistant to conventional treatment: improved symptoms with cephalosporin plus specific beta-lactamase inhibition. Microb Drug Resist 1995 Winter; 1(4):341-4.
  • Georgilis K, Peacocke M, Klempner MS. Fibroblasts protect the Lyme disease spirochete, Borrelia burgdorferi, from ceftriaxone in vitro. J Infect Dis 1992 Aug; 166(2):440-4.
  • Goldings AS, Taylor JP, Rawlings J. Lyme borreliosis in Texas. Tex Med 1991 Sep; 87(9):62-6.
  • Hold DA, Pattani NJ, Sinnott JT 4th, Bradley E. Lyme borreliosis. Infect Control Hosp Epidemiol. 1991 Aug; 12(8):493-6.
  • Hoffmann H. Lyme borreliosis – problems of serological diagnosis. Infection 1996. Nov-Dec; 24(6):470-2.
  • Hudson BJ, Steward M, Lennox VA, Fukunaga M, Yabuki M, et al. Culture-positive Lyme borreliosis. Med J Aust 1998 May 18; 168(10):500-2.
  • Klempner MS, Hu LT, Evans J, Schmid CH, Johnson GM, Trevino RP, Norton D, Levy L, Wall D, McCall J, Kosinski M, Weinstein A. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med 2001. Jul 12; 345(2):85-92.
  • Krupp, LB et al. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology, 2003. 60(12):p.1923-30.
  • Kufko IT, Mel’nikov VG, Andreeva EA, Sokolova ZI, Lesniak OM, Beikin laB. Comparative study of results of serological diagnosis of Lyme borreliosis by indirect immunofluorescence and immunoenzyme analysis. Klin Lab Diagn 1999; 3:34-7.
  • Lawrence C, Lipton RB, Lowy FD, Coyle PK. Seronegative chronic relapsing neuroborreliosis. Eur Neurol 1995; 35(2):113-7.
  • Luft BJ, Dattwyler RJ, Johnson RC, Luger SW, Bosler EM, Rahn DW, Masters EJ, Grunwaldt E, Gadgil SD. Azithromycin compared with amoxicillin in the treatment of erythema migrans. A double-blind, randomised, controlled trial. Ann Intern Med 1996 May 1; 124(9):785-91.
  • Luft BJ, Volkman DJ, Halperin JJ, Dattwyler RJ. New chemotherapeutic approaches in the treatment of Lyme borreliosis. Ann N Y Acad Sci 1988; 539:352-61.
  • MacDonald AB, Berger BW, Schwan TG. Clinical implications of delayed growth of the Lyme borreliosis spirochete, Borrelia burgdorferi. Acta Trop 1990. Dec; 48(2):89-94.
  • Mursic VP, Wanner G, reinhardt S, Wilske B, Busch U, Marget W. Formation and cultivation of Borrelia burgdorferi spheroplast L-form variants. Infection 1996; 24(3):218-26.
  • Oksi, J et al. Borrelia burgdorferi detected by culture and PCR in clinical relapse of disseminated Lyme borreliosis. Ann med, 1999. 31)3):p225-32.
  • Oksi J, Kalimo H, Marttila RJ, Marjamaki M, Sonninen P, Nikoskelainen J, Vilijanen MK. Inflammatory brain changes in Lyme borreliosis. A report on three patients and review of literature. Brain 1996. Dec; 119 (Pt6):2143-54.
  • Oksi, J et al. Comparison of oral cefixime and intravenous ceftriaxone followed by oral amoxicillin in disseminated Lyme borreliosis. Eur J Clin Microbiol Infect Dis, 1998. 17(10):p715-9.
  • Petrovic M, Vogelaers D, Van Renterghem, Carton D, De Reuck J, Afschrift M. Lyme borreliosis – a review of the late stages and treatment of four cases. Acta Clin Belg 1998. Jun 53(3):178-83.
  • Preac-Mursic V, Weber K, Pfister HW, Wilske B, Gross B, Baumann A, Prokop J. Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 1989 Nov-Dec; 17(6):355-9.
  • Schoen RT. Treatment of Lyme disease. Conn Med 1989. Jun; 53(6):335-7.
  • Steere AC. Lyme disease. N Engl J Med 1989. Aug 31; 321(9):586-96.
  • Straubinger RK. PCR-based quantification of Borrelia burgdorferi organisms in canine tissues over a 500-day postinfection period. J Clinical Microbiology 2000; 38(6):2191-2199.
  • Straubinger RK, Straubinger AF, Summers BA, Jacobson RH. Status of Borrelia burgdorferi infection after antibiotic treatment and the effects of corticosteroids: an experimental study. J Infectious Diseases 2000; 181(3):1069-1081.
  • Straubinger RK, Straubinger AF, Summers BA, Jacobson RH, Erb HN. Clinical and serologic follow-up in patients with neuroborreliosis. Neurology 1998 Nov; 51(5):1489-91.
  • Treib J, Fernandez A, Haass A, Grauer MT, Holzer G, Woessner R. Clinical and serologic follow-up in patients with neuroborreliosis. Neurology 1998 Nov; 51(5):1489-91.
  • Valesova H, Mailer J, Havlik J, Hulinska D, Hercogova J. Long-term results in patients with Lyme arthritis following treatment with ceftriaxone. Infection 1996; 24(1)98-102.
  • Weber K. Treatment failure in erythema migrans: a review. Infection 1996; 24:73-5.
  • Wolfe D, Fries C, Reynolds K, Hathcock L. The epidemiology of Lyme disease in Delaware 1989-1992. Del Med J 1994 Nov; 66(11):603-6, 609-13.
  • Wahlberg, P et al. Treatment of late Lyme borreliosis. J Infect, 1994. 29(3):p255-61.
  • Warner G, O’Connell S, Lawton N. Atypical features in three patients with florid neurological Lyme disease. J Neurol Neurosurg Psychiatry 1999; 67(2):275.
  • Waniek C, Prohovnik I, Kaufman MA, Dwork AJ. Rapidly progressive frontal-type dementia associated with Lyme disease. J Neuropsychiatry Clin Neurosci 1995. Summer, 7(3):345-7.
  • Zamponi N, Cardinali C, Tavoni, MA, Porfiri L, Rossi R, Manca A. Chronic neuroborreliosis in infancy. Ital J Neurol Sci 1999 Oct; 20(5):303-7.
  • Ziska MH, Donta ST, Demarest FC. Physician preferences in the diagnosis and treatment of Lyme disease in the United States. Infection 1996. Mar-Apr; 24(2):182-6.

 

Relapses and failures with short-term antibiotic therapy in Lyme Disease:

  • Logigian (1990): After 6 mo’s of therapy, 10/27 patients treated with IV AB’s relapsed or had treatment failure.
  • Pfister (1991): 33 patients with neuroborreliosis were treated with IV AB’s. After a mean of 8.1 months 10/27 were symptomatic and borrelia persisted in the CSF in 1 pt
  • Shadick (1994): 10/38 pts relapsed (5 with IV) within 1 year of treatment, and had repeated AB treatment
  • Asch (1994): 28% relapsed w/ major organ involvement 3.2 years after initial treatment
  • Aalesova (1996):10/26 relapsed or progressed at 36 mo
  • Trieb (1998): >50% pts symptomatic after 4.2/+/- 1.2 yrs
  • Shadick (1999): 69/184 (37%) report a previous relapse

 

Benefits of longer antibiotic therapy in disseminated Lyme Disease:

  • Wahlberg,P. et al, Treatment of late Lyme borreliosis. J Infect, 1994. 29(3): p255-61
  • Donta, ST., Tetracycline therapy for chronic Lyme disease. Clin Infect Dis, 1997. 25 Suppl 1: p.S52-6.
  • Oksi, J et al., Comparison of oral cefixime and intravenous ceftriaxone followed by oral amoxicillin in disseminated Lyme borreliosis. Eur J Clin Microbiol Infect Dis,1998.17(10):p715-19
  • Oksi, J., et al. Borrelia burgdorferi detected by culture and PCR in clinical relapse of disseminated Lyme borreliosis. Ann Med, 1999. 31(3):p.225-32

 

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